Medical database with symptom frequencies
Is there a large medical database with symptom frequencies for diseases? I.e. the percentage of patients with a specific disease that have specific symptoms?
For example (numbers and symptoms made up by me):
Barrett's esophagus:
longstanding heartburn 81.3%
dysphagia 72.5%
hematemesis 38.1%
unintentional weight loss 20.9%
COVID-19:
fever 51.2%
fatigue 17.1%
dry cough 66.0%
sneezing 26.2%
malaise 8.5%
The answer should not be several research papers that contain two or three different diseases with symptom frequencies each but a proper database containing hundreds if not thousands of diseases with symptom frequencies.
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What you're looking for is used by AI or Bayesian networks for online diagnosis. These databases are commercially sensitive and likely only accessible by API rather than raw data. For example, ISABEL, has been around for 20 years
www.isabelhealthcare.com/products/integration
Nature Communications have such a database.
Human symptoms–disease network
XueZhong Zhou, Jörg Menche, Albert-László Barabási & Amitabh Sharma
Published: 26 June 2014
They count the number of times a disease and a symptom keywords both appear on the same PudMed article, and assign a TF-IDF value to each pair.
In their words:
Acquisition of symptom and disease relationships
The association between symptoms and diseases were then quantified using term co-occurrence (number of PubMed identifiers in which two terms appear together;
Link to the database:
static-content.springer.com/esm/art%3A10.1038%2Fncomms5212/MediaObjects/41467_2014_BFncomms5212_MOESM1045_ESM.txt
(Supplementary Data 3 from the article)
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