: How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it? Both Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have been used to treat basal

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How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it?
Both Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have been used to treat basal cell carcinoma (BCC) with a fair amount of success (~60 to 90% success rate at 5-year follow-up) {1}.
Imiquimod and 5-Fluorouracil work differently, e.g. from {1}:

Imiquimod is a toll-like
receptor that modifies the immune response via the up-regulation of cytokines and has the capacity to improve a person’s
immune response.
5-Fluorouracil attacks cancer cells by inhibiting thymidylate
synthetase.

This makes me wonder: does it make sense to try 5-Fluorouracil in case Imiquimod 5% cream failed to treat a BCC. In other words, how effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it?

References:

{1} Love WE, Bernhard JD, Bordeaux JS. Topical imiquimod or
fluorouracil therapy for basal and squamous cell carcinoma: a
systematic review. Arch Dermatol. 2009;145(12):1431–8. doi.org/10.1001/archdermatol.2009.291

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