: Codeine vs Morphine competition for UGT2B7 and CYP3A4 Codeine and morphine are metabolized by the same key enzymes UGT2B7 and CYP3A4. Obviously codeine and morphine should inhibit each other's metabolism. Did anyone experimentally

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Codeine vs Morphine competition for UGT2B7 and CYP3A4
Codeine and morphine are metabolized by the same key enzymes UGT2B7 and CYP3A4. Obviously codeine and morphine should inhibit each other's metabolism.
Did anyone experimentally measure this competition using purified/recombinant enzymes?

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