: Is PCV13 effective if the suspension is not shaken prior to administration? PCV13, like other vaccines which are suspensions, should be shaken vigorously to obtain a homogenous, white suspension in the vaccine container immediately

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Is PCV13 effective if the suspension is not shaken prior to administration?
PCV13, like other vaccines which are suspensions, should be shaken vigorously to obtain a homogenous, white suspension in the vaccine container immediately prior to use.

If this is not done and the vaccine is administered as a clear liquid, will it still evoke an adequate immune response in the patient?

Edit: I am not questioning the necessity of 'shaking well before use' if it is explicitly mentioned on the label. What I want to know is whether the vaccine is rendered ineffective if this instruction is neglected. Would it necessitate re-immunization?

I ask this because I recently witnessed a health professional fail to shake the PCV13 prefilled syringe before use. When I brought this to her attention, she said that she was not aware of this and hadn't been doing it for any of the suspension/adjuvant vaccines. I wonder if there might be other health professionals who are unaware of this requirement. If so, how protected are the recipients of this important vaccine? Should they be re-immunized?

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