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Hoots : Do big people age faster? I learned that age is mutations across cells that become more common as you get older. Since a bigger person uses more calories and their cells die and are renewed more often, does that mean they - freshhoot.com

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Do big people age faster?
I learned that age is mutations across cells that become more common as you get older. Since a bigger person uses more calories and their cells die and are renewed more often, does that mean they have more mutations and age faster than normal?


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What you mean by "big people"? Obese? Very tall but not obese (BMI in proper range)?

My answer for obese: probably they do age faster, but this is not so easy to prove as we lack measurement tools to measure aging intself. Quote from Obesity accelerates epigenetic aging of human liver (2014):

Because obese people are at an increased risk of many age-related
diseases, it is a plausible hypothesis that obesity increases the
biological age of some tissues and cell types. However, it has been
difficult to detect such an accelerated aging effect because it is
unclear how to measure tissue age. Here we use a recently developed
biomarker of aging (known as “epigenetic clock”) to study the
relationship between epigenetic age and obesity in several human
tissues. We report an unexpectedly strong correlation between high
body mass index and the epigenetic age of liver tissue. This finding
may explain why obese people suffer from the early onset of many
age-related pathologies, including liver cancer.

Also:

Assessing tissue age poses a significant methodological challenge
because it is not clear which biomarkers of aging are appropriate.
There is a considerable debate in the literature as to what extent
markers/causes of cellular senescence, such as telomere length,
capture all aspects of tissue aging (8–10).

If you accept such biomarkers as telomere length:

Leukocyte telomere length, which is a widely used biomarker of aging,
has been found to be negatively correlated with body mass index (BMI)
(3–7). Although the observed correlation between BMI and telomere
length is relatively weak (r = 0.12) (4), it is remarkable that these
studies demonstrated that BMI is associated with an age acceleration
effect in blood.

Quote from 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue (2016):

Accordingly, understanding the interplay between accelerated ageing
related to obesity and adipose tissue dysfunction is critical to gain
insight into the ageing process in general as well as into the
pathophysiology of obesity and other related conditions. Here we
postulate the concept of 'adipaging' to illustrate the common links
between ageing and obesity and the fact that, to a great extent, obese
adults are prematurely aged individuals.


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