Effects of ARBs on potassium levels
Angiotensin II receptor blockers (ARBs) are commonly used to treat hypertension. One of the side effects of these drugs is to raise serum potassium levels. This occurs because ARBs block the effects of angiotensin II on receptors, which leads to reduced aldosterone production. Aldosterone causes retention of sodium and excretion of potassium, thereby lowering serum potassium levels.
My question is whether this effect is immediate or delayed. For example, if a person begins taking an ARB daily, will its effect on potassium levels be the same on day 1 as it will be on day 30?
Assume normal kidney function and no other drugs. If the particular ARB matters, consider losartan.
(1)1 Comments
Sorted by latest first Latest Oldest Best
Drug levels rise to reach a steady state in about 4-5 doses. Moreover, occurrence of increased potassium (hyperkalemia) also depends on other factors, especially kidney function. Hyperkalemia is much commoner if kidney function is impaired. Also, if person is on other drugs that cause rise in potassium, hyperkalemia is more likely. These drugs include ACE (angiotensin converting enzyme) inhibitors and spironolactone. These 2 are mentioned here since they are also used for conditions where ARBs may be used, namely heart failure and high blood pressure.
Quoting from 'DRUG INTERACTIONS' part of www.drugs.com/pro/losartan.html
As with other drugs that block angiotensin II or its effects,
concomitant use of potassium-sparing diuretics (e.g., spironolactone,
triamterene, amiloride), potassium supplements, or salt substitutes
containing potassium may lead to increases in serum potassium.
The effect on potassium is through blocking effect of aldosterone axis so it is an immediate effect.
Terms of Use Privacy policy Contact About Cancellation policy © freshhoot.com2026 All Rights reserved.