Does intermittent fasting induce autophagic cell death?
www.cancertherapyadvisor.com/home/tools/fact-sheets/intermittent-fasting-and-cancer/
In vitro and in vivo animal studies suggest that PF inactivates
pro-proliferative pathways, while enhancing differential stress
resistance in normal cells.2 Combined with the theory that cancer
cells are generally dependent on a highly nourishing environment with
a preference for high glucose levels, called the Warburg effect, this
resulted in the hypothesis that IF or PF can sensitize cancer cells to
chemotherapy or other anticancer therapies. In addition, other studies
have shown that fasting induces autophagy and can modulate the immune
system by activating CD8 cytotoxic T cells and inhibiting T-regulatory
cells.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4905302/
Autophagy is an evolutionarily conserved intracellular catabolic
process that is used by all cells to degrade dysfunctional or
unnecessary cytoplasmic components through delivery to the lysosome.
Increasing evidence reveals that autophagic dysfunction is associated
with human diseases, such as cancer. Paradoxically, although autophagy
is well recognized as a cell survival process that promotes tumor
development, it can also participate in a caspase-independent form of
programmed cell death. Induction of autophagic cell death by some
anticancer agents highlights the potential of this process as a cancer
treatment modality. Here, we review our current understanding of the
molecular mechanism of autophagy and the potential roles of autophagy
in cell death, cancer development, and cancer treatment.
After doing some research, it seems that autophagy plays a role in promoting and combating cancer cell growth, so I was wondering if the first quote above meant "autophagic cell death" instead of simply autophagy, which would make sense because cancer cells fools the body that they are normal to evade immune response. Does intermittent fasting induce autophagic cell death?
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