Does skeletal muscle injury cause hypertrophy or atrophy?
In the following diagram from the Love and Bailey textbook I see that injury causes a decrease in hypertrophy due to a decrease in the expression of IGF-1. Here Love and Bailey consider a skeletal muscle model.
But in Robbins and Cotran (diagram attached), mechanical stretch and growth factors like IGF-1 cause an increase in contractile protein synthesis. Here Robbins and Cotran consider a heart muscle as model.
So the question is whether injury causes hypertrophy or atrophy? I feel that if injury is beyond repair then atrophy should occur, but is this what Love and Bailey wanted to say or is it different? Does it depend on whether the muscle is skeletal muscle or cardiac muscle?
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The answer is hypertrophy, but if the injury is disabling, then it will lead to muscle atrophy due to disuse. Note that body builders lift weight until causing minor injury.
www.unm.edu/~lkravitz/Article%20folder/musclesgrowLK.html
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