: Fatal adult-onset blood/vascular disorder I'd like to know if there's a blood or vascular disease/disorder that fits, or could conceivably fit, all the following criteria, even if only in theory: Present from birth Onset

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Fatal adult-onset blood/vascular disorder
I'd like to know if there's a blood or vascular disease/disorder that fits, or could conceivably fit, all the following criteria, even if only in theory:

Present from birth
Onset of symptoms, or a sudden severe increase of symptoms, in young adulthood (anywhere from age 20 to 40, let's say)
Relatively high fatality rate
Incurable (though not necessarily untreatable)
Not restricted to developing societies; can affect upper-middle class Westerners

I've landed on sickle-cell anemia as a promising candidate, although I don't know whether it can fulfill criterion #2 .

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