Why do corticosteroids have few kidney-related side effects?
Prostaglandins are involved with promoting various renal functions. Therefore, NSAIDs, like indomethacin which inhibits protaglandin formation through COX enzyme inhibition, tend to have many side-effects related to the kidneys.
Since corticosteroids like prednisone also affects prostaglandin synthesis, why are there relatively fewer kidney-related side-effects of corticosteroids compared to NSAIDs?
(1)1 Comments
Sorted by latest first Latest Oldest Best
Corticosteroids block the enzyme Phospholipase A2 (PLA2) which catalyses the first step in arachidonic acid synthesis pathway. But, NSAIDs blocks activity of cyclooxygenases (COX 1 and COX 2).
So, by blocking this pathway at first step completely prevents the formation of of Arachidonic acid, but when this pathway is blocked later at step performed by COX enzyme, other inflammatory pathways are still active which are performed by Lipoxygenases (LOX). LOX enzyme is involved in synthesizes of leukotrienes which are responsible for inducing inflammatory damage to kidneys.
Terms of Use Privacy policy Contact About Cancellation policy © freshhoot.com2026 All Rights reserved.