What would happen if you administered endothelin during a myocardial infarction?
I have been going through the Rhodes medical physiology and have learned about Endothelin (specifically its role in hyperplasia) and collateral vessels in slowly developed [cardiovascular disease] (CVD). This makes me wonder the following things:
Why can we not avoid the scar tissue formation that plagues myocardial infarction (MI) survivors by administering Endothelin in a selective manner so as to make it only hit the type A receptors ?
How plastic are heart cells?
FYI: I have no idea how the heart controls its plasticity and cell growth, but given that cancers in the heart are so rare surely the administration of endothelin would be well regulated
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It seems to be still under debate. Contradictory evidence has been found.
The relative importance of Endothelin Type A and Endothelin Type B receptors during myocardial ischaemia are still debated.
The word you are seeking is regenerative. Mammalian hearts are made from non-regenerative tissue.
"While several animals can regenerate heart damage (e.g. the axolotl), mammalian cardiomyocytes (heart muscle cells) cannot proliferate (multiply) and heart damage causes scarring and fibrosis."
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