: Why is cushing's syndrome mainly associated with cortisol? When I hear Cushing's I always hear and think of cortisol excess. How come its cortisol that is mainly associated with this condition - more than mineralogical/

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Why is cushing's syndrome mainly associated with cortisol?
When I hear Cushing's I always hear and think of cortisol excess.

How come its cortisol that is mainly associated with this condition - more than mineralogical/ aldosterone or androgens?

I understand if its from taking glucocorticoids we would be talking just about cortisol - but even when talking about adrenal cushing's, such as in the picture below, most sources refer to cortisol first.

Do tumours in the adrenal gland act more on the zona fasiculata or something?

Thank you.

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