: What is the earliest research indicating tobacco products are addictive and/or harmful to the users health? Tobacco usage in the US (and the world) has impacted the lives of many. It's use and health risks has been the subject

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It very much depends on what you mean by evidence, but if you're talking about major studies that produced meaningful results that actually captured people's attention, it was a series of case-control studies in 1950's, followed by a fair amount of more intensive research in the late 1950's and early 1960's.

It's a somewhat technical paper, but this paper describes both some of the early results, the medical research community's reactions to them, and the broader impacts on medical research as a field.