How does vortioxetine cause nausea when it inhibits 5HT3-receptors?
5HT3 Inhibitors are antiemetics, such as Mirtazapine. See here and here
The serotonin modulator vortioxetine is such an inhibitor, and the most common side effect is nausea, in 3 it says that it has a 5HT3-inhibitor effect.
I am confused. Can someone explain the contradiction between explanations?
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Its primary action is as NaSSA (a noradrenergic and specific serotonergic antidepressant), not as 5-HT3 inhibitor. If you have a look at e. g. the Wikipedia page (https://en.wikipedia.org/wiki/Mirtazapine#Pharmacodynamics), you will see that nausea is listed as side effect under "discontinuation syndrome", i. e. sudden withdrawal from continuous 5-HT3 blocking.
As a side note, it also has H1-blocking effects, which are antiemetic as well.
There are more withdrawal symptoms listed here: www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Mirtazapine-(Remeron)
I was mistaken, the 5HT3 inhibitor of Vortioxetine is not responsible for the nausea, see here
Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but nausea has an important role on drug discontinuation.
Its additional antagonism of 5-HT3 receptors may partly counteract gastrointestinal adverse effects but nausea has an important role on drug discontinuation.
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