: Dr. prescribed Ondansetron/Zofran for migraines & says it'll help with weight loss too. How effective is it for either (migraines/weight loss)? I have suffered from migraines since my childhood, but I never grew out of it.

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Your question contains two parts. So I will address them separately.

First here a small background on ondansetron: Ondansetron is a selective antagonist at 5-HT3 receptors. It is most frequently used in the prevention of chemotherapy-induced nausea and vomiting.

How effective is Ondansetron/Zofran for treating migraines?

Ondansetron doesn't belong to the drug used in the management of nausea and vomiting in migraine. Actually, headache are the most common side effects of odansetron 1 2, so it is definitely not suitable in your case. Although you seem to have tested a lot of drugs against nausea and vomiting, the review by Lainez et al provides an excellent summary of the recommendations for nause and vomiting management in migraine (below). This might help you.

How effective is Ondansetron/Zofran for helping to lose weight?

I haven't found a study showing a link between ondansetron and weight loss. Though, recently, an experimental study conducted in mice, showed that tropisetron (which is also a 5-HT3R antagonist) reduced intestinal motility and almost completely blocked weight gain associated with glucose feeding.