Are there vaccines which have a varying effect on people of different ethnicities?
As per the New York Times:
Moderna’s problem seemed fitting for late summer 2020, when the United States was reeling from not just a pandemic but unrest over racial injustice. Dr. Slaoui informed Mr. Bancel that Moderna had not recruited enough minority candidates into its vaccine trials. If it could not prove its vaccine worked well for Black and Hispanic Americans, who have been disproportionately affected by the pandemic, it would not make it over the finish line.
Are there vaccines which work for humans of one ethnicity, but have a lesser efficacy for humans of a different efficacy? If not, why would medical authorities be concerned about recruiting humans of different ethnicities for the trial?
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Are there vaccines which work for humans of one ethnicity, but have a lesser efficacy for humans of a different efficacy?
Yes, e.g. influenza vaccine {1,2}. One reason is that some genes influence the anti-influenza antibody response, and some of these genes are correlated to the ethnicities. E.g., from {2}:
In addition, we analyzed ethnically diverse individuals within the 1000 genomes project and discovered marked variations in F- and L- genotypes and CN among the various ethnic groups that may impact HV1-69-sBnAb responses. These results have immediate implications for understanding HV1-69-sBnAb responses at the individual and population level and for the design and implementation of “universal” influenza vaccine.
References:
{1} Watson, Corey T., Jacob Glanville, and Wayne A. Marasco. "The individual and population genetics of antibody immunity." Trends in immunology 38, no. 7 (2017): 459-470. doi.org/10.1016/j.it.2017.04.003 {2} Avnir, Yuval, Corey T. Watson, Jacob Glanville, Eric C. Peterson, Aimee S. Tallarico, Andrew S. Bennett, Kun Qin et al. "IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity." Scientific Reports 6 (2016). www.ncbi.nlm.nih.gov/pmc/articles/PMC4754645/
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