: What to keep in mind when playing at high frets? When playing a melody or soloing around the top frets, 12-15, on electric guitar, is there anything specific to keep in mind? I'd guess the strings are more sensitive to accidental

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The action is likely to be higher in this area of the fretboard, which may slightly affect your fretting action
The tone of the notes for a given picking position will be mellower, because the lower harmonics will be excited relatively more
the speaking lengths of the strings will be thicker relative to their length, so the harmonic structure will be less "ideal" (the sound will have component frequencies that are further away from being integer multiples of the fundamental).
left hand muting is often easier, as the same light touch will damp the string faster