Grapefruit Seeds (not juice) and Cialis
My andrologist prescribed me Cialis and Cistonorm.
While reading Cialis leaflet I have discovered that grapefruit juice might affect how Cialis work and Cistonorm contains grapefruit seeds.
I know that seeds and juice are not the same thing, my doctor hasn't warned me about any issue that i might have and i have found that Cialis and Cistonorm are sometimes prescribed together, but still i'd like to have a specific answer and i have found nothing on the internet about grapefruit seeds and Cialis specifically.
So, can grapefruit seeds adversely affect Cialis the same way grapefruit juice does?
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Your question took me a while to research; it goes beyond basic medicine and delves into biochemistry, pharmacology, and physiology. The short answer is: Yes! It can; however, as you will see in the studies that are linked, it's dose dependent. From what I found, the primary culprit of drug interactions in grapefruit juice lies in naringenin; however, other compounds play a role as well. Naringenin is a natural compound (a flavonoid) found in fruits such as grapefruit, oranges, and tomatoes. The concentration of naringenin can be viewed in the following studies.
www.plantphysiol.org/content/77/4/903.full.pdf fshs.org/proceedings-o/2007-vol-120/FSHS%20vol.%20120/288-294.pdf
For general information on Grapefruit and it's drug interactions, you will find this article useful.
Unfortunately, I could not find a "critical level" that would cause increased drug interactions. In light of all the studies reviewed, the best course of action would be to avoid grapefruit in any form - juice, seed, or otherwise - in order to prevent any drug interaction. I hope this answers your question.
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