: What is the link between elevated estrogen and lowered alkaline phosphatase? This Wikipdia-article lists several conditions or diseases that may lead to reduced levels of alkaline phosphatase (AP). Among them are: postmenopausal

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What is the link between elevated estrogen and lowered alkaline phosphatase?
This Wikipdia-article lists several conditions or diseases that may lead to reduced levels of alkaline phosphatase (AP).

Among them are:

postmenopausal women receiving estrogen therapy because of aging
taking oral contraceptives (the linked study investigated combined OCP)

I assume, in both cases the hormones themselves (estrogen, maybe also progestogen) somehow influence the AP-levels.
If it is correct:

Is the reaction cascade known, that leads from the hormone(s) to the reduced AP levels?

So far, I could only find studies that confirmed there is a link between estrogen and AP levels, for example this or this. However, I am interested in the details here.

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