: Why do common diseases tend to be polyfactorial, while rare diseases often involve a single gene? This answer by xiota to Why do gene therapies so often target rare disease? states: Common diseases tend to be polyfactorial,

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Why do common diseases tend to be polyfactorial, while rare diseases often involve a single gene?
This answer by xiota to Why do gene therapies so often target rare disease? states:

Common diseases tend to be polyfactorial, while rare diseases often involve a single gene.?Many involve just a single mutation event (substitution, deletion, addition, inversion, etc).

Why do common diseases tend to be polyfactorial, while rare diseases often involve a single gene? One could think that it is more likely to have one single mutation than to have a combination of several factors.

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