Can cannabidiol help on Autism Spectrum Disorder?
Spanish doctor Mariano Garcia de Palau, aseverates in a cannabic website, childs with autism experiment improvements derived from the consume of non psychoactive compund of Cannabis, Cannabidiol (CBD).
Many of these children seem unhappy and have pain or are suffering
continuously, and at the beginning of treatment seems to change this
circumstance or at least improve, some smile and others laugh!
These small changes, for many insignificant ones, represent for the
parents a great step and some reasonable expectations, which did not
exist before.
CBD has been proved to regulate cytokines in rats, reducing proinflamatory cytokines and augmenting antiinflamatory ones (Napimoga et al, 2009).
As far as I know, it has been observed people with ASD have elevated cytokines in general (Ashwood et al, 2011).
I know there are not enoght studies of action of CBD, but it looks to act as an immunosupresant, while ASD is sugested to be related with autoimmunity.
My question is:
Can CBD be helpfull for autism because of actions on antibodies?
In other terms:
Can CBD interact negatively with other antibodies than cytokines, becoming harmfull (or helpfull) for an ASD?
-Paul Ashwood, Paula Krakowiak, Irva Hertz-Picciotto, Robin Hansen Isaac, Pessah Judy Van de Water (2011): "Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.", Brain, Behavior, and Immunity, Volume 25, Issue 1, Pages 40-45.
-Marcelo H. Napimoga, Bruno B. Benatti, Flavia O. Lima, Polyanna M. Alvesa, Allin C. Campos, Diego R. Pena-dos-Santos, Fernando P. Severino, Fernando Q. Cunha, Francisco S. Guimarães (2009): "Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats", International Immunopharmacology, Volume 9, Issue 2, Pages 216-222
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