: Why does a rise in cAMP potentiate PGI2? In my book Principles of Physiology (by Debasis Pramanik), it is mentioned that dipyridamole inhibits phosohodiesterase which increases cyclic adenosine monophosohate (cAMP) which

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Basically, the signal transduction pathway of PGI2 involves a Gs protein. This Gs protein involves the increase in cAMP (through adenylate cyclase; I am assuming you know the signal transduction pathways). Thus, when you administer Dipyridamole, phosphodiesterase is inhibited (which would've degraded your cAMP), thus there is an augmented effect of the PGI2.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3085271/ Go through this article and check out the first image there. On the very left of the image, you can find the PGI2 pathway.
Hope this helps :)