: Why aren't purine analogs effective in non-hematological malignancies? FDA has approved many purine analogs e.g. thioguanine, cladribine, pentostatin, mercaptopurine for various forms of leukemia and/or lymphoma, but none

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It's not a given, that they are not useful in solid tumors (also lymphoma are accounted among the solid tumors).

There are pyrimidine-like antimetabolites, e. g. 5-FU: en.wikipedia.org/wiki/Fluorouracil, while some purine antimetabolites were in development, see e. g. here: www.ncbi.nlm.nih.gov/pubmed/4066218.
There are some approaches that try to make tumors more sensitive to purine antimetabolites, e. g. www.sciencedirect.com/science/article/abs/pii/S0006295219304691.
Another, older, paper that describes a purine antimetabolite in lymphoma: ascopubs.org/doi/abs/10.1200/JCO.1991.9.1.175
A more recent approach on the purine metabolism: www.frontiersin.org/articles/10.3389/fimmu.2018.01697/full